To open, or not to open, that is NOT a question

The release of AlphaFold3 has triggered a lot of discussions. People acclaim better prediction result using AlphaFold3, not only predicting from peptide sequences to protein structures, but also predicting the protein binding with RNA, DNA, metal ions. This can help new drug development greatly!

However, some people criticize AlphaFold3 team did not disclose the codes.

Actually, it is not a new issue. The pharmaceutical companies protected the formula of their new medicine with patents. These pharmaceutical companies as well as AlphaFold3 team are sponsored by private sector funding, so the publishing of AlphaFold3 is more like commercial behavior, like new release of Apple products, instead of pure scientific research.

This is my point here, the new released AI models are commercial products instead of scientific achievements. We should lower our expectation of these new AI models

Update on May28,2024. I learned a new word “soft”!